What Are Cialis and Viagra Famous For?

These pills became a genuine breakthrough in ED treatment (ED hereinafter stands for erectile dysfunction). They were invented at approximately the same time, as sildenafil citrate appeared on the market in 1998, and five years later tadalafil came out. These are the active compounds of Viagra and Cialis, respectively. The former belongs to Pfizer Inc., a famous pharmaceutical company in the USA. The latter is manufactured by another American drug producer, Eli Lilly. Other well-known congeners of these medicines are avanafil branded as Stendra, udenafil a.k.a. Zydena, etc.

40% of adult men in America sooner or later face the inability to achieve and keep an erection firm and long enough for a normal sexual act. Viagra et al. successfully cures erectile dysfunction in approximately 70% of all cases. When you know these numbers, you do not have to ask why these drugs are so famous. Before they entered the market, men had to undergo complex and unsafe surgical procedures like vessel widening and implantation, or visit a therapist for ages waiting for a positive result.

There were vacuum devices, which used air pressure to drive blood to the penis. Not a romantic manipulation, do you agree? Men had to do it right before intercourse, and the misuse of such devices caused pain and tissue damage. Special injections that induced blood circulation in the penis were also available, but their common side effect was severe priapism. This is when a man has the opposite problem — a boner does not go away. Compare all this to a well-tolerated, effective, and fast-acting pill, which gives an erection right when you need it.

Sildenafil and Tadalafil: Mechanism of Action

The working compounds of both tablets belong to one family — PDE5 inhibitors. They alter the chemistry inside male genitals to induce blood circulation in the phallus. At the same time, they do not force an erection, they simply promote the natural response of the body to sexual stimulation. The whole process involves three bioactive compounds: nitric oxide (NO), cyclic guanosine monophosphate (cGMP), and phosphodiesterase type 5 (PDE5). When a man is sexually excited, no matter whether it is due to emotions, tactile sensations, or something he sees, his body produces NO and delivers it to the vessels of the penis. NO provides the local enhancement of cGMP. This signaling molecule is associated with the smooth muscles’ relaxation. This is how blood flows to the corpora cavernosa and makes the penis hard.

When the arousal goes down, PDE5 degrades cGMP, and the penis becomes flaccid. Erectile dysfunction occurs when something in this elaborate mechanism does not work properly. Sildenafil citrate, tadalafil, and cGMP have a similar chemical structure, so PDE5 binds to the molecules of the drugs instead of the cyclic nucleotide. Thus, the necessary messenger that provides vasodilation remains in the body in proper amounts. The only difference between tadalafil and sildenafil is that with the latter most men can get a boner as soon as 30 minutes after administration, but its effects wane in about 4-8 hours. Cialis has a longer onset of action, but works for a day and a half. Thus, if you take one pill on Friday evening, it will still work for you on Sunday morning.

Side Effects of Drugs

The side effects of all PDE5 inhibitors are almost the same, and the most common are:

• headache;
• heartburn;
• blurred vision;
• flushing;
• digestion problems.

Viagra consumers report that they have headaches and cardialgy stronger and more often than those who take Cialis. More dangerous adverse reactions are rare and are usually associated with overdose. They include hearing loss, various allergic responses, hypotension, heart attack and other cardiovascular ailments, stroke, priapism, etc.

These drugs can be taken either on a full or an empty stomach, but there are some precautions to take. Viagra is not absorbed properly if you eat high-fat food before taking a dosage. Alcohol and grapefruit, as well as its juice, should be avoided while you are taking any erection pills. The same works for certain medications, e.g. nitrates, hypotensives, antimycotics, anticonvulsants, antibiotics, the preparations for HIV, tuberculosis and hepatitis, etc. There is one common line in the list of interactions of all erection pills, which states that no one should mix them with the other PDE5 inhibitors. You should tell a medical specialist about all drugs you take and ask if they interact with Viagra or Cialis.

Choose the Right Dosage

Patients themselves should not establish a dosage for any medications, as this is a doctor’s job. This rule works for Viagra, too. Only a medical professional knows how to calculate the correct dosage considering previous health history, emotional state, all medications, and the lifestyle of his or her patient. This data significantly influences the eventual recommendations, and a doctor may even advise a man to try some other option, from psychotherapy to surgery.

We understand that such issues are rather hard to tell someone, whether it is a best friend or a therapist. Many men with ED prefer to cope with their problem on their own, using the experience of their companions in misfortune. If you also choose this way, you should adhere to the common strategy of professional health advisers. It is better to start with a lower dose and increase it only if required.

The recommended starting dose for Viagra is 50 mg half an hour before sex, being sure to have only one intake per day! The drug can be used on a daily basis, and this way the dosage may vary from 25 mg to 100 mg. Again, it is better to begin with the minimum strength for each serving, and attentively monitor how the body responds to the treatment. The half-life of sildenafil is about 3-5 hours, so you should coordinate your sexual activity and drug administration. Lovemaking will go successfully if it happens no later than four hours after the drug intake.

The recommended initial dosage for tadalafil is 5-10 mg. Keep in mind that this medication works slower but longer than Viagra, thus it must be administered at least one hour, and even better — two hours, before you and your partner hit the sheets. Cialis has one huge advantage over its competitors, as it continues to work for 36 hours. Thus, if you take it daily, you do not have to count how long after taking it you can have sexual intercourse, because the active compound is always present in your body system. The effect of tadalafil is somewhat less acute than that of sildenafil, but it is constant, and this is why it is much better for daily use.

What We Expect from Viagra and Cialis Combo?

The reason why men want to try Cialis and Viagra together is rooted in the difference of their onsets of action and half-lives. Mixing them, the individuals are trying to get the advantages of both drugs — a quick and strong effect that lasts for a couple of days. The other motive to use both pills at the same time is to find any solution when a standalone medication does not help. Men in such situations are ready to go to extremes and break the rules.

If you have found yourself in such a situation and made the firm decision to try stacking Viagra and Cialis, we advise you to talk with users who have already had such an experience. Again, it is better to stick to the lowest recommended dosages of both drugs in the beginning. There are a lot of reports on the net where men say that they used the minimum doses of two medications. Sometimes, Cialis is administered daily for benign prostatic hyperplasia, and Viagra — for erection, only as needed.

Some men mixed ED medications this way — they took Viagra one day and Cialis the next. Thus, a man can see through practice which tablet works more effectively for him. However, if you use Cialis first, it is better to wait one day more before using Viagra, in order to avoid any possible side effects of overdosing. Remember, that these drugs have the same effects, and combining them is more like taking an excessive dose of one of them. One important thing to remember is that if you take drugs differently than they are prescribed by your physician, you may run into certain problems with your insurance.

The Dangerous Effects of ED Drug Mix

What happens if you take two PDE5 inhibitors simultaneously? Most probably, your body will respond to it negatively. They both decrease blood pressure, thus there is a risk of dangerous hypotension, fainting, and dizziness. In fact, the risk and acuteness of any common side effect of both tablets can be doubled when they are taken together.

They all do the same job, be they positive or negative actions that they produce in your body. When they work together, their strength increases. However, you can barely have any additional benefits from this, as there won’t be two boners after two pills, right? On the contrary, the adverse reactions are multiplied this way. Thus, when you ask yourself the question “Can I take these two at once?” think first if you really need it.

Overcoming Priapism as Side Effect of Stacking

A frequent problem related to Viagra and Cialis misuse is priapism. When the level of sildenafil or tadalafil, not even speaking of both of them, is too high, the erection may not go away for hours. This situation only seems to be funny, as in reality it can result in acute pain, tissue damage, and penis disfigurement. Moreover, this leads to the further development of erectile dysfunction, making the ailment more serious.

In the case of a prolonged boner, the first aid is to apply some decongestant that contains pseudoephedrine. This active compound is used to cure nasal congestion, but it also relieves undesired and painful erections. The examples of such remedies are Wal-Act, Benadryl Plus, Nurofen Cold & Flu, Sudafed, etc. Still, this medication does not help everyone. If it does not help, you should contact your doctor immediately. By the way, this is another reason to follow the instructions when using medicines — when something goes wrong, you will have to explain why it happened. Are there any good explanations for overdosing on several ED pills?

Which ED Drug to Take?

Every man chooses the right tablets for himself. What works well today, may be ineffective next Friday. It all depends on the goals and methods of drug administration. For instance, Cialis is better for daily use due to its longer action. Also, one tadalafil tablet works for a whole weekend. Viagra works faster and provides stronger effects. It is good in situations when a romantic adventure happens unexpectedly. Both drugs are powerful remedies for erectile dysfunctions with scientifically proven effects, and none of them is unequivocally better than the other.

In the SildenafilViagra online pharmacy, every man can find safe and reputed medications for sexual health. We sell tablets that deliver sildenafil citrate or tadalafil to treat ED, and these medications are identical generics of the branded Viagra and Cialis. Why you should choose SildenafilViagra? Because we will not ask for a prescription from your doctor, and no one will know what exactly you receive in your package. We take care about your anonymity, as even your bank statement will not have any references to Viagra, sildenafil, ED drugs, etc. Moreover, we warmly welcome bitcoin payers and give them a 35% discount.

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